Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

The MYC oncogenic transcription factor is overexpressed in most human cases of T cell acute lymphoblastic leukemia (T-ALL), often downstream of mutational NOTCH1 activation. Genetic alterations in the PTEN–PI3K–AKT pathway are also common in T-ALL. We generated a conditional zebrafish model of T-ALL...

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Detalles Bibliográficos
Autores principales: Gutierrez, Alejandro, Grebliunaite, Ruta, Feng, Hui, Kozakewich, Elena, Zhu, Shizhen, Guo, Feng, Payne, Elspeth, Mansour, Marc, Dahlberg, Suzanne E., Neuberg, Donna S., den Hertog, Jeroen, Prochownik, Edward V., Testa, Joseph R., Harris, Marian, Kanki, John P., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149218/
https://www.ncbi.nlm.nih.gov/pubmed/21727187
http://dx.doi.org/10.1084/jem.20101691

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