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Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities

Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently used as rejuvenant therapy to overcome many discomforts and pr...

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Autores principales: Guruprasad, K. P., Mascarenhas, Roshan, Gopinath, P. M., Satyamoorthy, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149391/
https://www.ncbi.nlm.nih.gov/pubmed/21829300
http://dx.doi.org/10.4103/0975-9476.59826
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author Guruprasad, K. P.
Mascarenhas, Roshan
Gopinath, P. M.
Satyamoorthy, K.
author_facet Guruprasad, K. P.
Mascarenhas, Roshan
Gopinath, P. M.
Satyamoorthy, K.
author_sort Guruprasad, K. P.
collection PubMed
description Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently used as rejuvenant therapy to overcome many discomforts and prevent diseases. It has been reported that rasayanas have immunomodulatory, antioxidant and antitumor functions. However, the genotoxic potential of many rasayanas remains to be evaluated. The present study was undertaken to assess the role of Brahma rasayana(BR) on genotoxicity in vivo in a mouse test system. The older mice (9 months) were orally fed with rasayana for 8 weeks. The treated groups showed no signs of dose-dependent toxicity at the dosage levels tested. The body weight loss/gain and feed consumption were unaffected at tested doses. Furthermore, sperm abnormalities and chromosomal aberrations were insignificant in the treatment group when compared to controls. However, there was a marginal increase in sperm count in the BR treated animals. These findings clearly indicate that there are no observed adverse genotoxic effects elicited by BR in experimental animals such as mice.
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spelling pubmed-31493912011-08-09 Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities Guruprasad, K. P. Mascarenhas, Roshan Gopinath, P. M. Satyamoorthy, K. J Ayurveda Integr Med Experimental Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently used as rejuvenant therapy to overcome many discomforts and prevent diseases. It has been reported that rasayanas have immunomodulatory, antioxidant and antitumor functions. However, the genotoxic potential of many rasayanas remains to be evaluated. The present study was undertaken to assess the role of Brahma rasayana(BR) on genotoxicity in vivo in a mouse test system. The older mice (9 months) were orally fed with rasayana for 8 weeks. The treated groups showed no signs of dose-dependent toxicity at the dosage levels tested. The body weight loss/gain and feed consumption were unaffected at tested doses. Furthermore, sperm abnormalities and chromosomal aberrations were insignificant in the treatment group when compared to controls. However, there was a marginal increase in sperm count in the BR treated animals. These findings clearly indicate that there are no observed adverse genotoxic effects elicited by BR in experimental animals such as mice. Medknow Publications Pvt Ltd 2010 /pmc/articles/PMC3149391/ /pubmed/21829300 http://dx.doi.org/10.4103/0975-9476.59826 Text en © Journal of Ayurveda and Integrative Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Experimental
Guruprasad, K. P.
Mascarenhas, Roshan
Gopinath, P. M.
Satyamoorthy, K.
Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title_full Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title_fullStr Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title_full_unstemmed Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title_short Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities
title_sort studies on brahma rasayana in male swiss albino mice: chromosomal aberrations and sperm abnormalities
topic Experimental
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149391/
https://www.ncbi.nlm.nih.gov/pubmed/21829300
http://dx.doi.org/10.4103/0975-9476.59826
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