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Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

The pore-lining amino acids of ion channel proteins reside on the interface between a polar (the pore) and a nonpolar environment (the rest of the protein). The structural dynamics of this region, which physically controls ionic flow, are essential components of channel gating. Using large-conductan...

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Detalles Bibliográficos
Autores principales: Chen, Xixi, Aldrich, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149437/
https://www.ncbi.nlm.nih.gov/pubmed/21746846
http://dx.doi.org/10.1085/jgp.201110632