Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens

Presbyopia is closely associated with the loss of accommodation, and hence with a decline in the viscoelastic properties of the human eye lens. In this article we describe a method for obtaining spatially resolved in vivo measurements of the rheological properties of the eye lens, based on the spect...

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Autores principales: Reiß, Stephan, Burau, Gerolf, Stachs, Oliver, Guthoff, Rudolf, Stolz, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Ophthalmology Applications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149515/
https://www.ncbi.nlm.nih.gov/pubmed/21833354
http://dx.doi.org/10.1364/BOE.2.002144
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author Reiß, Stephan
Burau, Gerolf
Stachs, Oliver
Guthoff, Rudolf
Stolz, Heinrich
author_facet Reiß, Stephan
Burau, Gerolf
Stachs, Oliver
Guthoff, Rudolf
Stolz, Heinrich
author_sort Reiß, Stephan
collection PubMed
description Presbyopia is closely associated with the loss of accommodation, and hence with a decline in the viscoelastic properties of the human eye lens. In this article we describe a method for obtaining spatially resolved in vivo measurements of the rheological properties of the eye lens, based on the spectroscopic analysis of spontaneous Brillouin scattering using a virtually imaged phased array (VIPA). The multi-pass configuration enhances resolution to the extent that measurements are possible in elastic biological tissue characterized by intense scattering. We also present spatially resolved measurements obtained in extracted animal eyes and lenses. The results yield entirely new insights into the aging process of the eye lens.
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spelling pubmed-31495152011-08-10 Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens Reiß, Stephan Burau, Gerolf Stachs, Oliver Guthoff, Rudolf Stolz, Heinrich Biomed Opt Express Ophthalmology Applications Presbyopia is closely associated with the loss of accommodation, and hence with a decline in the viscoelastic properties of the human eye lens. In this article we describe a method for obtaining spatially resolved in vivo measurements of the rheological properties of the eye lens, based on the spectroscopic analysis of spontaneous Brillouin scattering using a virtually imaged phased array (VIPA). The multi-pass configuration enhances resolution to the extent that measurements are possible in elastic biological tissue characterized by intense scattering. We also present spatially resolved measurements obtained in extracted animal eyes and lenses. The results yield entirely new insights into the aging process of the eye lens. Optical Society of America 2011-07-05 /pmc/articles/PMC3149515/ /pubmed/21833354 http://dx.doi.org/10.1364/BOE.2.002144 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Ophthalmology Applications
Reiß, Stephan
Burau, Gerolf
Stachs, Oliver
Guthoff, Rudolf
Stolz, Heinrich
Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title_full Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title_fullStr Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title_full_unstemmed Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title_short Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens
title_sort spatially resolved brillouin spectroscopy to determine the rheological properties of the eye lens
topic Ophthalmology Applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149515/
https://www.ncbi.nlm.nih.gov/pubmed/21833354
http://dx.doi.org/10.1364/BOE.2.002144
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