Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target cell is destroyed. In cytotoxic T lymphocyte...

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Detalles Bibliográficos
Autores principales: Stinchcombe, Jane C, Salio, Mariolina, Cerundolo, Vincenzo, Pende, Daniela, Arico, Maurizo, Griffiths, Gillian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149597/
https://www.ncbi.nlm.nih.gov/pubmed/21711522
http://dx.doi.org/10.1186/1741-7007-9-45

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