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B7 Costimulation Molecules Encoded by Replication-Defective, vhs-Deficient HSV-1 Improve Vaccine-Induced Protection against Corneal Disease

Herpes simplex virus 1 (HSV-1) causes herpes stromal keratitis (HSK), a sight-threatening disease of the cornea for which no vaccine exists. A replication-defective, HSV-1 prototype vaccine bearing deletions in the genes encoding ICP8 and the virion host shutoff (vhs) protein reduces HSV-1 replicati...

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Detalles Bibliográficos
Autores principales:	Schrimpf, Jane E., Tu, Eleain M., Wang, Hong, Wong, Yee M., Morrison, Lynda A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149624/ https://www.ncbi.nlm.nih.gov/pubmed/21826207 http://dx.doi.org/10.1371/journal.pone.0022772

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