Cargando…

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma

BACKGROUND: Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown. METHODOLOGY/PRIN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sjölund, Jonas, Boström, Anna-Karin, Lindgren, David, Manna, Sugata, Moustakas, Aristidis, Ljungberg, Börje, Johansson, Martin, Fredlund, Erik, Axelson, Håkan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149633/ https://www.ncbi.nlm.nih.gov/pubmed/21826227 http://dx.doi.org/10.1371/journal.pone.0023057

Ejemplares similares

Gas6 and the Receptor Tyrosine Kinase Axl in Clear Cell Renal Cell Carcinoma
por: Gustafsson, Anna, et al.
Publicado: (2009)

Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma
por: Sitaram, Raviprakash T., et al.
Publicado: (2016)

Notch signaling is necessary for epithelial growth arrest by TGF-β
por: Niimi, Hideki, et al.
Publicado: (2007)

Features of increased malignancy in eosinophilic clear cell renal cell carcinoma
por: Nilsson, Helén, et al.
Publicado: (2020)

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells
por: Stockhausen, M-T, et al.
Publicado: (2005)

Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice
por: Johansson, Elinn, et al.
Publicado: (2016)

Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma
por: de Alwis, Roger, et al.
Publicado: (2023)

Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma
por: Mallikarjuna, Pramod, et al.
Publicado: (2019)

TGF-β Signaling
por: Tzavlaki, Kalliopi, et al.
Publicado: (2020)

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels
por: Fritz, Helena K., et al.
Publicado: (2015)

Specific Genomic Aberrations Predict Survival, But Low Mutation Rate in Cancer Hot Spots, in Clear Cell Renal Cell Carcinoma
por: Köhn, Linda, et al.
Publicado: (2015)

Single Nucleotide Polymorphisms in the Wilms’ Tumour Gene 1 in Clear Cell Renal Cell Carcinoma
por: Li, Xingru, et al.
Publicado: (2013)

Long non‐coding RNAs and TGF‐β signaling in cancer
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2020)

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate
por: Nilsson, H, et al.
Publicado: (2015)

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
por: Moustakas, Aristidis, et al.
Publicado: (2016)

DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma
por: Evelönn, Emma Andersson, et al.
Publicado: (2019)

CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney
por: Nyström, Jenny, et al.
Publicado: (2009)

Alteration of Gene Expression Signatures of Cortical Differentiation and Wound Response in Lethal Clear Cell Renal Cell Carcinomas
por: Zhao, Hongjuan, et al.
Publicado: (2009)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
por: Thomasson, Marcus, et al.
Publicado: (2012)

Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma
por: Andersson-Evelönn, Emma, et al.
Publicado: (2020)

Frequency and distribution of Notch mutations in tumor cell lines
por: Mutvei, Anders Peter, et al.
Publicado: (2015)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

NUAK1 and NUAK2 Fine-Tune TGF-β Signaling
por: van de Vis, Reinofke A. J., et al.
Publicado: (2021)

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
por: Caja, Laia, et al.
Publicado: (2018)

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom
por: Huminiecki, Lukasz, et al.
Publicado: (2009)

Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells
por: Korpetinou, Angeliki, et al.
Publicado: (2013)

TGFβ induces SIK to negatively regulate type I receptor kinase signaling
por: Kowanetz, Marcin, et al.
Publicado: (2008)

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
por: Gélabert, Caroline, et al.
Publicado: (2023)

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
por: Bellomo, Claudia, et al.
Publicado: (2017)

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
por: Chisari, Andrea, et al.
Publicado: (2021)

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation
por: Morén, Anita, et al.
Publicado: (2019)

Tensin3 Is a Negative Regulator of Cell Migration and All Four Tensin Family Members Are Downregulated in Human Kidney Cancer
por: Martuszewska, Danuta, et al.
Publicado: (2009)

Invasive cells follow Snail’s slow and persistent pace
por: García de Herreros, Antonio, et al.
Publicado: (2014)

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies
por: Peleli, Maria, et al.
Publicado: (2020)

VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma
por: Mallikarjuna, Pramod, et al.
Publicado: (2018)

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2019)

Size-based isolation and detection of renal carcinoma cells from whole blood
por: De Alwis, Roger, et al.
Publicado: (2022)

Orellanine specifically targets renal clear cell carcinoma
por: Buvall, Lisa, et al.
Publicado: (2017)

Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden
por: Hemminki, Kari, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_33udu7a0nafl1frqunge6vpa9u