The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications

Tissue engineering involves using the principles of biology, chemistry and engineering to design a ‘neotissue’ that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold gro...

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Detalles Bibliográficos
Autores principales: Oragui, Emeka, Nannaparaju, Madhusudhan, Khan, Wasim S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149843/
https://www.ncbi.nlm.nih.gov/pubmed/21886691
http://dx.doi.org/10.2174/1874325001105010267
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author Oragui, Emeka
Nannaparaju, Madhusudhan
Khan, Wasim S
author_facet Oragui, Emeka
Nannaparaju, Madhusudhan
Khan, Wasim S
author_sort Oragui, Emeka
collection PubMed
description Tissue engineering involves using the principles of biology, chemistry and engineering to design a ‘neotissue’ that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. We discuss the role of bioreactors in tissue engineering and evaluate the principles of bioreactor design. We evaluate the methods of cell stimulation and review the bioreactors in common use today.
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spelling pubmed-31498432011-08-30 The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications Oragui, Emeka Nannaparaju, Madhusudhan Khan, Wasim S Open Orthop J Article Tissue engineering involves using the principles of biology, chemistry and engineering to design a ‘neotissue’ that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. We discuss the role of bioreactors in tissue engineering and evaluate the principles of bioreactor design. We evaluate the methods of cell stimulation and review the bioreactors in common use today. Bentham Open 2011-07-28 /pmc/articles/PMC3149843/ /pubmed/21886691 http://dx.doi.org/10.2174/1874325001105010267 Text en © Oragui et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Oragui, Emeka
Nannaparaju, Madhusudhan
Khan, Wasim S
The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title_full The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title_fullStr The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title_full_unstemmed The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title_short The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications
title_sort role of bioreactors in tissue engineering for musculoskeletal applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149843/
https://www.ncbi.nlm.nih.gov/pubmed/21886691
http://dx.doi.org/10.2174/1874325001105010267
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