Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations

One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors...

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Autores principales: Kennard, Lucinda, Thanabalasundaram, Gopiga, Tailor, Hiteshkumar D, Khan, Wasim S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149860/
https://www.ncbi.nlm.nih.gov/pubmed/21892368
http://dx.doi.org/10.2174/1874325001105010249
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author Kennard, Lucinda
Thanabalasundaram, Gopiga
Tailor, Hiteshkumar D
Khan, Wasim S
author_facet Kennard, Lucinda
Thanabalasundaram, Gopiga
Tailor, Hiteshkumar D
Khan, Wasim S
author_sort Kennard, Lucinda
collection PubMed
description One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.
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spelling pubmed-31498602011-09-02 Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations Kennard, Lucinda Thanabalasundaram, Gopiga Tailor, Hiteshkumar D Khan, Wasim S Open Orthop J Article One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression. Bentham Open 2011-07-28 /pmc/articles/PMC3149860/ /pubmed/21892368 http://dx.doi.org/10.2174/1874325001105010249 Text en © Kennard et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Kennard, Lucinda
Thanabalasundaram, Gopiga
Tailor, Hiteshkumar D
Khan, Wasim S
Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title_full Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title_fullStr Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title_full_unstemmed Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title_short Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
title_sort advances and developments in the use of human mesenchymal stem cells – a few considerations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149860/
https://www.ncbi.nlm.nih.gov/pubmed/21892368
http://dx.doi.org/10.2174/1874325001105010249
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