Development of automated imaging and analysis for zebrafish chemical screens.

We demonstrate the application of image-based high-content screening (HCS) methodology to identify small molecules that can modulate the FGF/RAS/MAPK pathway in zebrafish embryos. The zebrafish embryo is an ideal system for in vivo high-content chemical screens. The 1-day old embryo is approximately...

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Detalles Bibliográficos
Autores principales: Vogt, Andreas, Codore, Hiba, Day, Billy W., Hukriede, Neil A., Tsang, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2010
Materias:
Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149986/
https://www.ncbi.nlm.nih.gov/pubmed/20613708
http://dx.doi.org/10.3791/1900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149986/
https://www.ncbi.nlm.nih.gov/pubmed/20613708
http://dx.doi.org/10.3791/1900

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