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The Role of GABAergic Inhibition in Ocular Dominance Plasticity

During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disord...

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Detalles Bibliográficos
Autores principales: Heimel, J. Alexander, van Versendaal, Daniëlle, Levelt, Christiaan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150150/
https://www.ncbi.nlm.nih.gov/pubmed/21826276
http://dx.doi.org/10.1155/2011/391763
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author Heimel, J. Alexander
van Versendaal, Daniëlle
Levelt, Christiaan N.
author_facet Heimel, J. Alexander
van Versendaal, Daniëlle
Levelt, Christiaan N.
author_sort Heimel, J. Alexander
collection PubMed
description During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity. One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation. Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity. Here, we discuss the current state of knowledge in the field and open questions to be addressed.
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spelling pubmed-31501502011-08-08 The Role of GABAergic Inhibition in Ocular Dominance Plasticity Heimel, J. Alexander van Versendaal, Daniëlle Levelt, Christiaan N. Neural Plast Review Article During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity. One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation. Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity. Here, we discuss the current state of knowledge in the field and open questions to be addressed. Hindawi Publishing Corporation 2011 2011-08-02 /pmc/articles/PMC3150150/ /pubmed/21826276 http://dx.doi.org/10.1155/2011/391763 Text en Copyright © 2011 J. Alexander Heimel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Heimel, J. Alexander
van Versendaal, Daniëlle
Levelt, Christiaan N.
The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title_full The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title_fullStr The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title_full_unstemmed The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title_short The Role of GABAergic Inhibition in Ocular Dominance Plasticity
title_sort role of gabaergic inhibition in ocular dominance plasticity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150150/
https://www.ncbi.nlm.nih.gov/pubmed/21826276
http://dx.doi.org/10.1155/2011/391763
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