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Animal Models of Calcific Aortic Valve Disease
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150155/ https://www.ncbi.nlm.nih.gov/pubmed/21826258 http://dx.doi.org/10.4061/2011/364310 |
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author | Sider, Krista L. Blaser, Mark C. Simmons, Craig A. |
author_facet | Sider, Krista L. Blaser, Mark C. Simmons, Craig A. |
author_sort | Sider, Krista L. |
collection | PubMed |
description | Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD. |
format | Online Article Text |
id | pubmed-3150155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31501552011-08-08 Animal Models of Calcific Aortic Valve Disease Sider, Krista L. Blaser, Mark C. Simmons, Craig A. Int J Inflam Review Article Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD. SAGE-Hindawi Access to Research 2011-08-02 /pmc/articles/PMC3150155/ /pubmed/21826258 http://dx.doi.org/10.4061/2011/364310 Text en Copyright © 2011 Krista L. Sider et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sider, Krista L. Blaser, Mark C. Simmons, Craig A. Animal Models of Calcific Aortic Valve Disease |
title | Animal Models of Calcific Aortic Valve Disease |
title_full | Animal Models of Calcific Aortic Valve Disease |
title_fullStr | Animal Models of Calcific Aortic Valve Disease |
title_full_unstemmed | Animal Models of Calcific Aortic Valve Disease |
title_short | Animal Models of Calcific Aortic Valve Disease |
title_sort | animal models of calcific aortic valve disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150155/ https://www.ncbi.nlm.nih.gov/pubmed/21826258 http://dx.doi.org/10.4061/2011/364310 |
work_keys_str_mv | AT siderkristal animalmodelsofcalcificaorticvalvedisease AT blasermarkc animalmodelsofcalcificaorticvalvedisease AT simmonscraiga animalmodelsofcalcificaorticvalvedisease |