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Animal Models of Calcific Aortic Valve Disease

Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be...

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Detalles Bibliográficos
Autores principales: Sider, Krista L., Blaser, Mark C., Simmons, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150155/
https://www.ncbi.nlm.nih.gov/pubmed/21826258
http://dx.doi.org/10.4061/2011/364310
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author Sider, Krista L.
Blaser, Mark C.
Simmons, Craig A.
author_facet Sider, Krista L.
Blaser, Mark C.
Simmons, Craig A.
author_sort Sider, Krista L.
collection PubMed
description Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD.
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spelling pubmed-31501552011-08-08 Animal Models of Calcific Aortic Valve Disease Sider, Krista L. Blaser, Mark C. Simmons, Craig A. Int J Inflam Review Article Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD. SAGE-Hindawi Access to Research 2011-08-02 /pmc/articles/PMC3150155/ /pubmed/21826258 http://dx.doi.org/10.4061/2011/364310 Text en Copyright © 2011 Krista L. Sider et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sider, Krista L.
Blaser, Mark C.
Simmons, Craig A.
Animal Models of Calcific Aortic Valve Disease
title Animal Models of Calcific Aortic Valve Disease
title_full Animal Models of Calcific Aortic Valve Disease
title_fullStr Animal Models of Calcific Aortic Valve Disease
title_full_unstemmed Animal Models of Calcific Aortic Valve Disease
title_short Animal Models of Calcific Aortic Valve Disease
title_sort animal models of calcific aortic valve disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150155/
https://www.ncbi.nlm.nih.gov/pubmed/21826258
http://dx.doi.org/10.4061/2011/364310
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