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Protein Targeting and Degradation are Coupled for Elimination of Mislocalized Proteins
A substantial proportion of the genome encodes membrane proteins that are delivered to the endoplasmic reticulum by dedicated targeting pathways(1). Membrane proteins that fail targeting must be rapidly degraded to avoid aggregation and disruption of cytosolic protein homeostasis(2,3). The mechanism...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150218/ https://www.ncbi.nlm.nih.gov/pubmed/21743475 http://dx.doi.org/10.1038/nature10181 |