Cargando…
Integrating Signals from the T-Cell Receptor and the Interleukin-2 Receptor
T cells orchestrate the adaptive immune response, making them targets for immunotherapy. Although immunosuppressive therapies prevent disease progression, they also leave patients susceptible to opportunistic infections. To identify novel drug targets, we established a logical model describing T-cel...
Autores principales: | Beyer, Tilo, Busse, Mandy, Hristov, Kroum, Gurbiel, Slavyana, Smida, Michal, Haus, Utz-Uwe, Ballerstein, Kathrin, Pfeuffer, Frank, Weismantel, Robert, Schraven, Burkhart, Lindquist, Jonathan A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150289/ https://www.ncbi.nlm.nih.gov/pubmed/21829342 http://dx.doi.org/10.1371/journal.pcbi.1002121 |
Ejemplares similares
-
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation
threshold in T cells
por: Smida, Michal, et al.
Publicado: (2013) -
A Logical Model Provides Insights into T Cell Receptor Signaling
por: Saez-Rodriguez, Julio, et al.
Publicado: (2007) -
Simulated Evolution of Signal Transduction Networks
por: Mobashir, Mohammad, et al.
Publicado: (2012) -
Negative Interactions and Feedback Regulations Are Required for Transient Cellular Response
por: Mobashir, Mohammad, et al.
Publicado: (2014) -
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of K(v)1.3 channels and T cell responsiveness
por: Lowinus, Theresa, et al.
Publicado: (2016)