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Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report

INTRODUCTION: Common variable immunodeficiency encompasses a group of heterogeneous conditions linked by a lack of immunoglobulin production and primary antibody failure. Although primary immunodeficiencies are typically characterized by recurrent infections, autoimmune manifestations have increasin...

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Autores principales: Sempere, Angel P, Tahoces, ML, Palao-Duarte, Susana, Garcia-Perez, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150318/
https://www.ncbi.nlm.nih.gov/pubmed/21771303
http://dx.doi.org/10.1186/1752-1947-5-319
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author Sempere, Angel P
Tahoces, ML
Palao-Duarte, Susana
Garcia-Perez, Alfonso
author_facet Sempere, Angel P
Tahoces, ML
Palao-Duarte, Susana
Garcia-Perez, Alfonso
author_sort Sempere, Angel P
collection PubMed
description INTRODUCTION: Common variable immunodeficiency encompasses a group of heterogeneous conditions linked by a lack of immunoglobulin production and primary antibody failure. Although primary immunodeficiencies are typically characterized by recurrent infections, autoimmune manifestations have increasingly been recognized. Neurological complications are extremely rare and to the best of our knowledge optic neuritis has not been described previously. We report the case of a patient with common variable immunodeficiency who developed loss of vision secondary to bilateral optic neuritis. CASE PRESENTATION: A 26-year-old Caucasian man with a diagnosis of common variable immunodeficiency presented to our facility with loss of vision secondary to bilateral optic neuritis. Results of a thorough study for infectious, neoplastic and autoimmune diseases were negative. Our patient was treated with intravenous methylprednisolone with almost complete improvement and he remained asymptomatic at a 12-month follow-up. CONCLUSIONS: Bilateral optic neuritis should be added to the list of autoimmune disorders related to common variable immunodeficiency. If a patient with common variable immunodeficiency experiences loss of vision, the possibility of bilateral optic neuritis should be considered as rapid initiation of high-dose corticosteroids may improve visual recovery.
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spelling pubmed-31503182011-08-05 Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report Sempere, Angel P Tahoces, ML Palao-Duarte, Susana Garcia-Perez, Alfonso J Med Case Reports Case Report INTRODUCTION: Common variable immunodeficiency encompasses a group of heterogeneous conditions linked by a lack of immunoglobulin production and primary antibody failure. Although primary immunodeficiencies are typically characterized by recurrent infections, autoimmune manifestations have increasingly been recognized. Neurological complications are extremely rare and to the best of our knowledge optic neuritis has not been described previously. We report the case of a patient with common variable immunodeficiency who developed loss of vision secondary to bilateral optic neuritis. CASE PRESENTATION: A 26-year-old Caucasian man with a diagnosis of common variable immunodeficiency presented to our facility with loss of vision secondary to bilateral optic neuritis. Results of a thorough study for infectious, neoplastic and autoimmune diseases were negative. Our patient was treated with intravenous methylprednisolone with almost complete improvement and he remained asymptomatic at a 12-month follow-up. CONCLUSIONS: Bilateral optic neuritis should be added to the list of autoimmune disorders related to common variable immunodeficiency. If a patient with common variable immunodeficiency experiences loss of vision, the possibility of bilateral optic neuritis should be considered as rapid initiation of high-dose corticosteroids may improve visual recovery. BioMed Central 2011-07-19 /pmc/articles/PMC3150318/ /pubmed/21771303 http://dx.doi.org/10.1186/1752-1947-5-319 Text en Copyright ©2011 Sempere et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sempere, Angel P
Tahoces, ML
Palao-Duarte, Susana
Garcia-Perez, Alfonso
Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title_full Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title_fullStr Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title_full_unstemmed Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title_short Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
title_sort bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150318/
https://www.ncbi.nlm.nih.gov/pubmed/21771303
http://dx.doi.org/10.1186/1752-1947-5-319
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