Extended Interferon-Alpha Therapy Accelerates Telomere Length Loss in Human Peripheral Blood T Lymphocytes

BACKGROUND: Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocyte...

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Detalles Bibliográficos
Autores principales: O'Bryan, Joel M., Potts, James A., Bonkovsky, Herbert L., Mathew, Anuja, Rothman, Alan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150344/
https://www.ncbi.nlm.nih.gov/pubmed/21829595
http://dx.doi.org/10.1371/journal.pone.0020922

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