Live-Cell Microscopy Reveals Small Molecule Inhibitor Effects on MAPK Pathway Dynamics

Oncogenic mutations in the mitogen activated protein kinase (MAPK) pathway are prevalent in human tumors, making this pathway a target of drug development efforts. Recently, ATP-competitive Raf inhibitors were shown to cause MAPK pathway activation via Raf kinase priming in wild-type BRaf cells and...

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Detalles Bibliográficos
Autores principales: Anderson, Daniel J., Durieux, Jenni K., Song, Kyung, Alvarado, Ryan, Jackson, Peter K., Hatzivassiliou, Georgia, Ludlam, Mary J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150364/
https://www.ncbi.nlm.nih.gov/pubmed/21829637
http://dx.doi.org/10.1371/journal.pone.0022607

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