Long Term Transcriptional Reactivation of Epigenetically Silenced Genes in Colorectal Cancer Cells Requires DNA Hypomethylation and Histone Acetylation

Epigenetic regulation of genes involves the coordination of DNA methylation and histone modifications to maintain transcriptional status. These two features are frequently disrupted in malignancy such that critical genes succumb to inactivation. 5-aza-2′-deoxycytidine (5-aza-dC) is an agent which in...

Descripción completa

Detalles Bibliográficos
Autores principales: Mossman, David, Scott, Rodney J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150411/
https://www.ncbi.nlm.nih.gov/pubmed/21829702
http://dx.doi.org/10.1371/journal.pone.0023127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150411/
https://www.ncbi.nlm.nih.gov/pubmed/21829702
http://dx.doi.org/10.1371/journal.pone.0023127

Ejemplares similares