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Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report

African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We perfor...

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Autores principales: Barbalic, Maja, Reiner, Alex P., Wu, Chunyuan, Hixson, James E., Franceschini, Nora, Eaton, Charles B., Heiss, Gerardo, Couper, David, Mosley, Thomas, Boerwinkle, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150445/
https://www.ncbi.nlm.nih.gov/pubmed/21829389
http://dx.doi.org/10.1371/journal.pgen.1002199
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author Barbalic, Maja
Reiner, Alex P.
Wu, Chunyuan
Hixson, James E.
Franceschini, Nora
Eaton, Charles B.
Heiss, Gerardo
Couper, David
Mosley, Thomas
Boerwinkle, Eric
author_facet Barbalic, Maja
Reiner, Alex P.
Wu, Chunyuan
Hixson, James E.
Franceschini, Nora
Eaton, Charles B.
Heiss, Gerardo
Couper, David
Mosley, Thomas
Boerwinkle, Eric
author_sort Barbalic, Maja
collection PubMed
description African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2,905 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. We identified a genome-wide significant SNP (rs1859023, MAF = 31%) located at 7q21 near the PFTK1 gene (HR = 0.57, 95% CI 0.46 to 0.69, p = 1.86×10(−08)), which replicated in an independent sample of over 8,000 African American women from the Women's Health Initiative (WHI) (HR = 0.81, 95% CI 0.70 to 0.93, p = 0.005). PFTK1 encodes a serine/threonine-protein kinase, PFTAIRE-1, that acts as a cyclin-dependent kinase regulating cell cycle progression and cell proliferation. This is the first finding of incident CHD locus identified by GWAS in African Americans.
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spelling pubmed-31504452011-08-09 Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report Barbalic, Maja Reiner, Alex P. Wu, Chunyuan Hixson, James E. Franceschini, Nora Eaton, Charles B. Heiss, Gerardo Couper, David Mosley, Thomas Boerwinkle, Eric PLoS Genet Research Article African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2,905 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. We identified a genome-wide significant SNP (rs1859023, MAF = 31%) located at 7q21 near the PFTK1 gene (HR = 0.57, 95% CI 0.46 to 0.69, p = 1.86×10(−08)), which replicated in an independent sample of over 8,000 African American women from the Women's Health Initiative (WHI) (HR = 0.81, 95% CI 0.70 to 0.93, p = 0.005). PFTK1 encodes a serine/threonine-protein kinase, PFTAIRE-1, that acts as a cyclin-dependent kinase regulating cell cycle progression and cell proliferation. This is the first finding of incident CHD locus identified by GWAS in African Americans. Public Library of Science 2011-08-04 /pmc/articles/PMC3150445/ /pubmed/21829389 http://dx.doi.org/10.1371/journal.pgen.1002199 Text en Barbalic et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Barbalic, Maja
Reiner, Alex P.
Wu, Chunyuan
Hixson, James E.
Franceschini, Nora
Eaton, Charles B.
Heiss, Gerardo
Couper, David
Mosley, Thomas
Boerwinkle, Eric
Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title_full Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title_fullStr Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title_full_unstemmed Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title_short Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report
title_sort genome-wide association analysis of incident coronary heart disease (chd) in african americans: a short report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150445/
https://www.ncbi.nlm.nih.gov/pubmed/21829389
http://dx.doi.org/10.1371/journal.pgen.1002199
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