Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

For many complex traits, genetic variants have been found associated. However, it is still mostly unclear through which downstream mechanism these variants cause these phenotypes. Knowledge of these intermediate steps is crucial to understand pathogenesis, while also providing leads for potential ph...

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Detalles Bibliográficos
Autores principales: Fehrmann, Rudolf S. N., Jansen, Ritsert C., Veldink, Jan H., Westra, Harm-Jan, Arends, Danny, Bonder, Marc Jan, Fu, Jingyuan, Deelen, Patrick, Groen, Harry J. M., Smolonska, Asia, Weersma, Rinse K., Hofstra, Robert M. W., Buurman, Wim A., Rensen, Sander, Wolfs, Marcel G. M., Platteel, Mathieu, Zhernakova, Alexandra, Elbers, Clara C., Festen, Eleanora M., Trynka, Gosia, Hofker, Marten H., Saris, Christiaan G. J., Ophoff, Roel A., van den Berg, Leonard H., van Heel, David A., Wijmenga, Cisca, te Meerman, Gerard J., Franke, Lude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150446/
https://www.ncbi.nlm.nih.gov/pubmed/21829388
http://dx.doi.org/10.1371/journal.pgen.1002197

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