H2AX Prevents CtIP-Mediated DNA End Resection and Aberrant Repair in G1-Phase Lymphocytes

DNA double stranded breaks (DSBs) are generated by the RAG endonuclease in all developing lymphocytes as they assemble antigen receptor genes(1). DNA cleavage by RAG occurs only at the G1-phase of the cell cycle and generates two hairpin-sealed DNA (coding) ends that require nucleolytic opening prio...

Descripción completa

Detalles Bibliográficos
Autores principales: Helmink, Beth A., Tubbs, Anthony T., Dorsett, Yair, Bednarski, Jeffrey J., Walker, Laura M., Feng, Zhihui, Sharma, Girdhar, McKinnon, Peter J., Zhang, Junran, Bassing, Craig H., Sleckman, Barry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150591/
https://www.ncbi.nlm.nih.gov/pubmed/21160476
http://dx.doi.org/10.1038/nature09585

Ejemplares similares

Ejemplares similares