Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1

Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (NR5A2) regulates bile acid biosynthesis(1,2). Structural studies have identified phospholipids as potential LRH-1 ligands(3–5), but their functional relevance is unclear. Here we show that an unusual...

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Detalles Bibliográficos
Autores principales: Lee, Jae Man, Lee, Yoon Kwang, Mamrosh, Jennifer L., Busby, Scott A., Griffin, Patrick R., Pathak, Manish C., Ortlund, Eric A., Moore, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150801/
https://www.ncbi.nlm.nih.gov/pubmed/21614002
http://dx.doi.org/10.1038/nature10111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150801/
https://www.ncbi.nlm.nih.gov/pubmed/21614002
http://dx.doi.org/10.1038/nature10111

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