Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities

Two Drosophila myosin II point mutations (D45 and Mhc(5)) generate Drosophila cardiac phenotypes that are similar to dilated or restrictive human cardiomyopathies. Our homology models suggest that the mutations (A261T in D45, G200D in Mhc(5)) could stabilize (D45) or destabilize (Mhc(5)) loop 1 of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Bloemink, Marieke J., Melkani, Girish C., Dambacher, Corey M., Bernstein, Sanford I., Geeves, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151086/
https://www.ncbi.nlm.nih.gov/pubmed/21680742
http://dx.doi.org/10.1074/jbc.M111.258228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151086/
https://www.ncbi.nlm.nih.gov/pubmed/21680742
http://dx.doi.org/10.1074/jbc.M111.258228

Ejemplares similares