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Evaluating target silencing by short hairpin RNA mediated by the group I intron in cultured mammalian cells
BACKGROUND: The group I intron, a ribozyme that catalyzes its own splicing reactions in the absence of proteins in vitro, is a potential target for rational engineering and attracted our interest due to its potential utility in gene repair using trans-splicing. However, the ribozyme activity of a gr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151216/ https://www.ncbi.nlm.nih.gov/pubmed/21781346 http://dx.doi.org/10.1186/1472-6750-11-79 |