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Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major histocompatibility complex (MHC) class II molecules...

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Detalles Bibliográficos
Autores principales:	Zou, Fang, Schäfer, Nadja, Palesch, David, Brücken, Ruth, Beck, Alexander, Sienczyk, Marcin, Kalbacher, Hubert, Sun, ZiLin, Boehm, Bernhard O., Burster, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151250/ https://www.ncbi.nlm.nih.gov/pubmed/21850236 http://dx.doi.org/10.1371/journal.pone.0022815

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