Pulmonary Oxidative Stress Is Increased in Cyclooxygenase-2 Knockdown Mice with Mild Pulmonary Hypertension Induced by Monocrotaline

The aim of this study was to examine the role of cyclooxygenase-2 (COX-2) and downstream signaling of prostanoids in the pathogenesis of pulmonary hypertension (PH) using mice with genetically manipulated COX-2 expression. COX-2 knockdown (KD) mice, characterized by 80–90% suppression of COX-2, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Seta, Francesca, Rahmani, Mahboubeh, Turner, Patricia V., Funk, Colin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151294/
https://www.ncbi.nlm.nih.gov/pubmed/21850273
http://dx.doi.org/10.1371/journal.pone.0023439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151294/
https://www.ncbi.nlm.nih.gov/pubmed/21850273
http://dx.doi.org/10.1371/journal.pone.0023439

Ejemplares similares