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Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging

The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Luo, Shuqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151592/
https://www.ncbi.nlm.nih.gov/pubmed/21892370
http://dx.doi.org/10.2174/1874431101105010019
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author Zhang, Lu
Luo, Shuqian
author_facet Zhang, Lu
Luo, Shuqian
author_sort Zhang, Lu
collection PubMed
description The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues by the use of X-ray phase shift. It is a new choice in terms of non-invasively revealing soft tissue details. In this study, the lung and hepatic fibrosis models of mice and rats were used to investigate the ability of PCI in microstructures observation of soft tissues. Our results demonstrated that different liver fibrosis stages could be distinguished non-invasively by PCI. The three-dimensional morphology of a segment of blood vessel was constructed. Noteworthy, the blood clot inside the vessel was visualized in three dimensions which provided a precise description of vessel stenosis. Furthermore, the whole lung airways including the alveoli were obtained. We had specifically highlighted its use in the visualization and assessment of the alveoli. To our knowledge, this was the first time for non-invasive alveoli imaging using PCI. This finding may offer a new perspective on the diagnosis of respiratory disease. All the results confirmed that PCI will be a valuable tool in biological soft tissues imaging.
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spelling pubmed-31515922011-09-02 Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging Zhang, Lu Luo, Shuqian Open Med Inform J Article The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues by the use of X-ray phase shift. It is a new choice in terms of non-invasively revealing soft tissue details. In this study, the lung and hepatic fibrosis models of mice and rats were used to investigate the ability of PCI in microstructures observation of soft tissues. Our results demonstrated that different liver fibrosis stages could be distinguished non-invasively by PCI. The three-dimensional morphology of a segment of blood vessel was constructed. Noteworthy, the blood clot inside the vessel was visualized in three dimensions which provided a precise description of vessel stenosis. Furthermore, the whole lung airways including the alveoli were obtained. We had specifically highlighted its use in the visualization and assessment of the alveoli. To our knowledge, this was the first time for non-invasive alveoli imaging using PCI. This finding may offer a new perspective on the diagnosis of respiratory disease. All the results confirmed that PCI will be a valuable tool in biological soft tissues imaging. Bentham Open 2011-07-27 /pmc/articles/PMC3151592/ /pubmed/21892370 http://dx.doi.org/10.2174/1874431101105010019 Text en © Zhang and Luo; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Zhang, Lu
Luo, Shuqian
Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title_full Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title_fullStr Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title_full_unstemmed Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title_short Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging
title_sort micro soft tissues visualization based on x-ray phase-contrast imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151592/
https://www.ncbi.nlm.nih.gov/pubmed/21892370
http://dx.doi.org/10.2174/1874431101105010019
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