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(Z)-6-Hy­droxy-1a,5-dimethyl-8-[(morpholin-4-yl)meth­yl]-2,3,6,7,7a,8,10a,10b-octa­hydro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-9(1aH)-one

The title compound, C(19)H(29)NO(5), was synthesized from 9α-hy­droxy­parthenolide (9α-hy­droxy-4,8-dimethyl-12-methylen-3,14-dioxatricyclo­[9.3.0.0(2),(4)]tetra­dec-7-en-13-one), which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The mol­ecule is built up from...

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Detalles Bibliográficos
Autores principales: Moumou, Mohamed, Benharref, Ahmed, Berraho, Moha, El Ammari, Lahcen, Akssira, Mohamed, Elhakmaoui, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151749/
https://www.ncbi.nlm.nih.gov/pubmed/21837095
http://dx.doi.org/10.1107/S1600536811022616
Descripción
Sumario:The title compound, C(19)H(29)NO(5), was synthesized from 9α-hy­droxy­parthenolide (9α-hy­droxy-4,8-dimethyl-12-methylen-3,14-dioxatricyclo­[9.3.0.0(2),(4)]tetra­dec-7-en-13-one), which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The mol­ecule is built up from two fused five- and ten-membered rings with the (morpholin-4-yl)methyl group as a substituent. The five-membered lactone ring has an envelope conformation, whereas the ten-membered and the morpholine rings display approximate chair–chair and chair conformations, respectively. The dihedral angle between the ten-membered ring and the lactone ring is 27.93 (6)°. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen-bond inter­actions. An intra­molecular O—H⋯N hydrogen bond also occurs.