8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1

The common DNA base modification 8-oxo-7,8-dihydroguanine (8-oxo-G) affects the efficiency and fidelity of transcription. We constructed plasmid substrates carrying single 8-oxo-G residues, specifically positioned in the transcribed or the non-transcribed DNA strands, to investigate their effects on...

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Detalles Bibliográficos
Autores principales: Kitsera, Nataliya, Stathis, Dimitrios, Lühnsdorf, Bork, Müller, Heiko, Carell, Thomas, Epe, Bernd, Khobta, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152326/
https://www.ncbi.nlm.nih.gov/pubmed/21441539
http://dx.doi.org/10.1093/nar/gkr163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152326/
https://www.ncbi.nlm.nih.gov/pubmed/21441539
http://dx.doi.org/10.1093/nar/gkr163

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