Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

Recent studies indicate that the DNA recognition domain of transcription activator-like (TAL) effectors can be combined with the nuclease domain of FokI restriction enzyme to produce TAL effector nucleases (TALENs) that, in pairs, bind adjacent DNA target sites and produce double-strand breaks betwe...

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Detalles Bibliográficos
Autores principales: Li, Ting, Huang, Sheng, Zhao, Xuefeng, Wright, David A., Carpenter, Susan, Spalding, Martin H., Weeks, Donald P., Yang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152341/
https://www.ncbi.nlm.nih.gov/pubmed/21459844
http://dx.doi.org/10.1093/nar/gkr188

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