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Zinc is essential for high-affinity DNA binding and recombinase activity of φC31 integrase

The mechanism through which the large serine recombinases bind DNA is poorly understood. Alignments of ϕC31 integrase (Int) and its relatives indicate the presence of a conserved motif containing four cysteines resembling a zinc finger. Inductively coupled plasma–mass spectrometry (ICP–MS) confirmed...

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Detalles Bibliográficos
Autores principales:	McEwan, Andrew R., Raab, Andrea, Kelly, Sharon M., Feldmann, Jörg, Smith, Margaret C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152356/ https://www.ncbi.nlm.nih.gov/pubmed/21507889 http://dx.doi.org/10.1093/nar/gkr220

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