Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation

Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA). We show here that fission yeast Cdt1 interacts with PCNA in vivo and...

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Detalles Bibliográficos
Autores principales: Guarino, Estrella, Shepherd, Marianne E. A., Salguero, Israel, Hua, Hui, Deegan, Rachel S., Kearsey, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152358/
https://www.ncbi.nlm.nih.gov/pubmed/21493688
http://dx.doi.org/10.1093/nar/gkr222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152358/
https://www.ncbi.nlm.nih.gov/pubmed/21493688
http://dx.doi.org/10.1093/nar/gkr222

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