How does DNA break during chromosomal translocations?

Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades,...

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Detalles Bibliográficos
Autores principales: Nambiar, Mridula, Raghavan, Sathees C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152359/
https://www.ncbi.nlm.nih.gov/pubmed/21498543
http://dx.doi.org/10.1093/nar/gkr223
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author Nambiar, Mridula
Raghavan, Sathees C.
author_facet Nambiar, Mridula
Raghavan, Sathees C.
author_sort Nambiar, Mridula
collection PubMed
description Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations.
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spelling pubmed-31523592011-08-08 How does DNA break during chromosomal translocations? Nambiar, Mridula Raghavan, Sathees C. Nucleic Acids Res Survey and Summary Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations. Oxford University Press 2011-08 2011-04-15 /pmc/articles/PMC3152359/ /pubmed/21498543 http://dx.doi.org/10.1093/nar/gkr223 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Nambiar, Mridula
Raghavan, Sathees C.
How does DNA break during chromosomal translocations?
title How does DNA break during chromosomal translocations?
title_full How does DNA break during chromosomal translocations?
title_fullStr How does DNA break during chromosomal translocations?
title_full_unstemmed How does DNA break during chromosomal translocations?
title_short How does DNA break during chromosomal translocations?
title_sort how does dna break during chromosomal translocations?
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152359/
https://www.ncbi.nlm.nih.gov/pubmed/21498543
http://dx.doi.org/10.1093/nar/gkr223
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