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Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue
BACKGROUND: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152534/ https://www.ncbi.nlm.nih.gov/pubmed/21771307 http://dx.doi.org/10.1186/1752-0509-5-115 |
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author | Yde, Pernille Mengel, Benedicte Jensen, Mogens H Krishna, Sandeep Trusina, Ala |
author_facet | Yde, Pernille Mengel, Benedicte Jensen, Mogens H Krishna, Sandeep Trusina, Ala |
author_sort | Yde, Pernille |
collection | PubMed |
description | BACKGROUND: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them. RESULTS: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves. CONCLUSIONS: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response. |
format | Online Article Text |
id | pubmed-3152534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31525342011-08-09 Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue Yde, Pernille Mengel, Benedicte Jensen, Mogens H Krishna, Sandeep Trusina, Ala BMC Syst Biol Research Article BACKGROUND: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them. RESULTS: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves. CONCLUSIONS: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response. BioMed Central 2011-07-19 /pmc/articles/PMC3152534/ /pubmed/21771307 http://dx.doi.org/10.1186/1752-0509-5-115 Text en Copyright ©2011 Yde et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yde, Pernille Mengel, Benedicte Jensen, Mogens H Krishna, Sandeep Trusina, Ala Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title | Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title_full | Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title_fullStr | Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title_full_unstemmed | Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title_short | Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue |
title_sort | modeling the nf-κb mediated inflammatory response predicts cytokine waves in tissue |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152534/ https://www.ncbi.nlm.nih.gov/pubmed/21771307 http://dx.doi.org/10.1186/1752-0509-5-115 |
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