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Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation

BACKGROUND: Long-term survival of patients with hepatocellular carcinoma (HCC) after liver transplantation is affected mainly by recurrence of HCC. There is the opinion that the chance of recurrence after 2 years post-transplantation is remote, and therefore lifelong surveillance is not justified be...

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Autores principales: Chok, Kenneth S. H., Chan, See Ching, Cheung, Tan To, Chan, Albert C. Y., Fan, Sheung Tat, Lo, Chung Mau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152711/
https://www.ncbi.nlm.nih.gov/pubmed/21597889
http://dx.doi.org/10.1007/s00268-011-1146-z
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author Chok, Kenneth S. H.
Chan, See Ching
Cheung, Tan To
Chan, Albert C. Y.
Fan, Sheung Tat
Lo, Chung Mau
author_facet Chok, Kenneth S. H.
Chan, See Ching
Cheung, Tan To
Chan, Albert C. Y.
Fan, Sheung Tat
Lo, Chung Mau
author_sort Chok, Kenneth S. H.
collection PubMed
description BACKGROUND: Long-term survival of patients with hepatocellular carcinoma (HCC) after liver transplantation is affected mainly by recurrence of HCC. There is the opinion that the chance of recurrence after 2 years post-transplantation is remote, and therefore lifelong surveillance is not justified because of limited resources. The aims of the present study were to determine the rate of late HCC recurrence (≥2 years after transplantation) and to compare the long-term patient survival outcomes between cases of early recurrence (<2 years after transplantation) and late recurrence. PATIENTS: A total of 139 adult HCC patients having liver transplantation during the period from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. Thirty-two patients received deceased-donor grafts and 107 received living-donor grafts. RESULTS: Hepatocellular carcinoma recurrence occurred in 24 (17.3%) patients, among them 22 (86%) had living-donor grafts and 7 (5%) developed late recurrence. Patients in the early recurrence group and patients in the late recurrence group had comparable demographics and disease pathology. The former group, when compared with the latter, had significantly worse overall survival at 3 years (13.3 versus 100%) and 5 years (6.67 versus 71.4%) (log-rank test; p < 0.001). CONCLUSIONS: Both early recurrence and late recurrence of HCC after liver transplantation were not uncommon, mostly detected at a subclinical stage. Regular and long-term surveillance with imaging and blood tests is essential for early detection.
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spelling pubmed-31527112011-09-21 Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation Chok, Kenneth S. H. Chan, See Ching Cheung, Tan To Chan, Albert C. Y. Fan, Sheung Tat Lo, Chung Mau World J Surg Article BACKGROUND: Long-term survival of patients with hepatocellular carcinoma (HCC) after liver transplantation is affected mainly by recurrence of HCC. There is the opinion that the chance of recurrence after 2 years post-transplantation is remote, and therefore lifelong surveillance is not justified because of limited resources. The aims of the present study were to determine the rate of late HCC recurrence (≥2 years after transplantation) and to compare the long-term patient survival outcomes between cases of early recurrence (<2 years after transplantation) and late recurrence. PATIENTS: A total of 139 adult HCC patients having liver transplantation during the period from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. Thirty-two patients received deceased-donor grafts and 107 received living-donor grafts. RESULTS: Hepatocellular carcinoma recurrence occurred in 24 (17.3%) patients, among them 22 (86%) had living-donor grafts and 7 (5%) developed late recurrence. Patients in the early recurrence group and patients in the late recurrence group had comparable demographics and disease pathology. The former group, when compared with the latter, had significantly worse overall survival at 3 years (13.3 versus 100%) and 5 years (6.67 versus 71.4%) (log-rank test; p < 0.001). CONCLUSIONS: Both early recurrence and late recurrence of HCC after liver transplantation were not uncommon, mostly detected at a subclinical stage. Regular and long-term surveillance with imaging and blood tests is essential for early detection. Springer-Verlag 2011-05-20 2011 /pmc/articles/PMC3152711/ /pubmed/21597889 http://dx.doi.org/10.1007/s00268-011-1146-z Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Chok, Kenneth S. H.
Chan, See Ching
Cheung, Tan To
Chan, Albert C. Y.
Fan, Sheung Tat
Lo, Chung Mau
Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title_full Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title_fullStr Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title_full_unstemmed Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title_short Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
title_sort late recurrence of hepatocellular carcinoma after liver transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152711/
https://www.ncbi.nlm.nih.gov/pubmed/21597889
http://dx.doi.org/10.1007/s00268-011-1146-z
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