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Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats

BACKGROUND: Amino acids have been reported to act as modulators of various regulatory processes and to provide new therapeutic applications for either the prevention or treatment of metabolic disorders. The purpose of the present study is to investigate the effects of single oral dose administration...

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Autores principales: Ardiansyah, Shirakawa, Hitoshi, Inagawa, Yuto, Koseki, Takuya, Komai, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152873/
https://www.ncbi.nlm.nih.gov/pubmed/21831334
http://dx.doi.org/10.1186/1743-7075-8-45
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author Ardiansyah
Shirakawa, Hitoshi
Inagawa, Yuto
Koseki, Takuya
Komai, Michio
author_facet Ardiansyah
Shirakawa, Hitoshi
Inagawa, Yuto
Koseki, Takuya
Komai, Michio
author_sort Ardiansyah
collection PubMed
description BACKGROUND: Amino acids have been reported to act as modulators of various regulatory processes and to provide new therapeutic applications for either the prevention or treatment of metabolic disorders. The purpose of the present study is to investigate the effects of single oral dose administration and a continuous treatment of L-tryptophan (L-Trp) on the regulation of blood pressure and glucose metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). METHODS: First, male 9-week-old SHRSP were administered 100 mg L-Trp·kg(-1 )body weight in saline to the L-Trp group and 0.9% saline to the control group via a gastric tube as a single oral dose of L-Trp. Second, three groups of SHRSP were fed an AIN-93M-based diet supplemented with L-tryptophan (L-Trp) (0, 200, or 1000 mg·kg(-1 )diet) for 3 weeks as continuous treatment of L-Trp. RESULTS: Single oral dose administration of L-Trp improved blood pressure, blood glucose, and insulin levels. Blood pressure, blood glucose, and insulin levels improved significantly in the L-Trp treatment groups. The administration of L-Trp also significantly increased plasma nitric oxide and serotonin levels. CONCLUSION: L-Trp by both single oral dose administration and continuous treatment improves glucose metabolism and blood pressure in SHRSP.
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spelling pubmed-31528732011-08-10 Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats Ardiansyah Shirakawa, Hitoshi Inagawa, Yuto Koseki, Takuya Komai, Michio Nutr Metab (Lond) Research BACKGROUND: Amino acids have been reported to act as modulators of various regulatory processes and to provide new therapeutic applications for either the prevention or treatment of metabolic disorders. The purpose of the present study is to investigate the effects of single oral dose administration and a continuous treatment of L-tryptophan (L-Trp) on the regulation of blood pressure and glucose metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). METHODS: First, male 9-week-old SHRSP were administered 100 mg L-Trp·kg(-1 )body weight in saline to the L-Trp group and 0.9% saline to the control group via a gastric tube as a single oral dose of L-Trp. Second, three groups of SHRSP were fed an AIN-93M-based diet supplemented with L-tryptophan (L-Trp) (0, 200, or 1000 mg·kg(-1 )diet) for 3 weeks as continuous treatment of L-Trp. RESULTS: Single oral dose administration of L-Trp improved blood pressure, blood glucose, and insulin levels. Blood pressure, blood glucose, and insulin levels improved significantly in the L-Trp treatment groups. The administration of L-Trp also significantly increased plasma nitric oxide and serotonin levels. CONCLUSION: L-Trp by both single oral dose administration and continuous treatment improves glucose metabolism and blood pressure in SHRSP. BioMed Central 2011-06-28 /pmc/articles/PMC3152873/ /pubmed/21831334 http://dx.doi.org/10.1186/1743-7075-8-45 Text en Copyright ©2011 Ardiansyah et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ardiansyah
Shirakawa, Hitoshi
Inagawa, Yuto
Koseki, Takuya
Komai, Michio
Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title_full Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title_fullStr Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title_full_unstemmed Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title_short Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats
title_sort regulation of blood pressure and glucose metabolism induced by l-tryptophan in stroke-prone spontaneously hypertensive rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152873/
https://www.ncbi.nlm.nih.gov/pubmed/21831334
http://dx.doi.org/10.1186/1743-7075-8-45
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