Cargando…

Epidermal stem cell dynamics

Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2, under the control of either the cytokeratin 14 (K14) or cytokeratin 15 (K15) promoter....

Descripción completa

Detalles Bibliográficos
Autor principal: Sieber-Blum, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152997/
https://www.ncbi.nlm.nih.gov/pubmed/21722345
http://dx.doi.org/10.1186/scrt70
_version_ 1782209827995385856
author Sieber-Blum, Maya
author_facet Sieber-Blum, Maya
author_sort Sieber-Blum, Maya
collection PubMed
description Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2, under the control of either the cytokeratin 14 (K14) or cytokeratin 15 (K15) promoter. Smoothened encodes a G-protein-coupled receptor protein in the hedgehog pathway, the misregulation of which is implicated in BCC and other human cancers. Chronic injury is thought to be a contributing factor. The authors used K14 as a marker for stem cells in the basal layer of the epidermis and K15 as a marker for epidermal stem cells in the bulge of hair follicles. Upon activation, K14 construct-bearing mice readily formed BCC-like tumours, whereas this was not the case in K15:SmoM2-carrying mice. Upon wounding the epidermis, however, there was widespread BCC-like tumour formation in the skin of K15:SmoM2 mice. The authors conclude that wounding recruited bulge epidermal stem cells to the surface, allowing the cells to escape quiescence in the stem cell niche and to arrive in an environment where the hedgehog pathway becomes activated and therefore tumorigenesis is elicited. While this is a provocative result and the authors' conclusion may well be correct, there are alternative explanations.
format Online
Article
Text
id pubmed-3152997
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-31529972012-06-29 Epidermal stem cell dynamics Sieber-Blum, Maya Stem Cell Res Ther Commentary Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2, under the control of either the cytokeratin 14 (K14) or cytokeratin 15 (K15) promoter. Smoothened encodes a G-protein-coupled receptor protein in the hedgehog pathway, the misregulation of which is implicated in BCC and other human cancers. Chronic injury is thought to be a contributing factor. The authors used K14 as a marker for stem cells in the basal layer of the epidermis and K15 as a marker for epidermal stem cells in the bulge of hair follicles. Upon activation, K14 construct-bearing mice readily formed BCC-like tumours, whereas this was not the case in K15:SmoM2-carrying mice. Upon wounding the epidermis, however, there was widespread BCC-like tumour formation in the skin of K15:SmoM2 mice. The authors conclude that wounding recruited bulge epidermal stem cells to the surface, allowing the cells to escape quiescence in the stem cell niche and to arrive in an environment where the hedgehog pathway becomes activated and therefore tumorigenesis is elicited. While this is a provocative result and the authors' conclusion may well be correct, there are alternative explanations. BioMed Central 2011-06-29 /pmc/articles/PMC3152997/ /pubmed/21722345 http://dx.doi.org/10.1186/scrt70 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Commentary
Sieber-Blum, Maya
Epidermal stem cell dynamics
title Epidermal stem cell dynamics
title_full Epidermal stem cell dynamics
title_fullStr Epidermal stem cell dynamics
title_full_unstemmed Epidermal stem cell dynamics
title_short Epidermal stem cell dynamics
title_sort epidermal stem cell dynamics
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152997/
https://www.ncbi.nlm.nih.gov/pubmed/21722345
http://dx.doi.org/10.1186/scrt70
work_keys_str_mv AT sieberblummaya epidermalstemcelldynamics