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Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK

Background: Equine dysautonomia or equine grass sickness (EGS), as it is more commonly known, is a usually fatal disease of equids of uncertain etiology, although associated with grazing, that affects the autonomic and enteric nervous system. Lowered gastrointestinal motility, leading to paralysis o...

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Autores principales: Edwards, Sarah E., Martz, Kathrin E., Rogge, Anja, Heinrich, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153002/
https://www.ncbi.nlm.nih.gov/pubmed/21833167
http://dx.doi.org/10.3389/fphar.2010.00122
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author Edwards, Sarah E.
Martz, Kathrin E.
Rogge, Anja
Heinrich, Michael
author_facet Edwards, Sarah E.
Martz, Kathrin E.
Rogge, Anja
Heinrich, Michael
author_sort Edwards, Sarah E.
collection PubMed
description Background: Equine dysautonomia or equine grass sickness (EGS), as it is more commonly known, is a usually fatal disease of equids of uncertain etiology, although associated with grazing, that affects the autonomic and enteric nervous system. Lowered gastrointestinal motility, leading to paralysis of the gut, is one of the main symptoms of EGS. Previous studies have implicated anaerobic bacteria, notably Clostridium botulinum, but what triggers the severe bacterial infestations remains enigmatic. We hypothesized that a detailed comparison of soil mineral and botanical composition of EGS and control sites would yield new insights into the causation of the disease. Results: Between March 2007 and September 2008, soil, plant, and water samples from a total of 23 EGS sites and 11 control sites were studied. Metal and non-metal element levels of the soil and herbage samples were assessed. Significantly, EGS sites had higher levels of soil nitrogen, and significantly higher levels of iron, lead, arsenic, and chromium in the herbage. Toxic Ranunculus spp. (buttercups) were found in abundance at every EGS site, making ingestion plausible. Conversely, neurotoxin-producing cyanobacteria were not found in any of the water samples analyzed. Conclusions: The significantly higher levels of iron and heavy metals found in herbage growing in EGS sites, in addition to toxic Ranunculus species, suggest that previously unknown triggers are involved in a multi-factorial EGS etiology. Our results also show that cyanobacteria on the other hand, are unlikely to be a factor in EGS. Consequently, the concomitant presence of two (or more) factors could be the trigger for an outbreak of EGS.
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spelling pubmed-31530022011-08-10 Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK Edwards, Sarah E. Martz, Kathrin E. Rogge, Anja Heinrich, Michael Front Pharmacol Neuroscience Background: Equine dysautonomia or equine grass sickness (EGS), as it is more commonly known, is a usually fatal disease of equids of uncertain etiology, although associated with grazing, that affects the autonomic and enteric nervous system. Lowered gastrointestinal motility, leading to paralysis of the gut, is one of the main symptoms of EGS. Previous studies have implicated anaerobic bacteria, notably Clostridium botulinum, but what triggers the severe bacterial infestations remains enigmatic. We hypothesized that a detailed comparison of soil mineral and botanical composition of EGS and control sites would yield new insights into the causation of the disease. Results: Between March 2007 and September 2008, soil, plant, and water samples from a total of 23 EGS sites and 11 control sites were studied. Metal and non-metal element levels of the soil and herbage samples were assessed. Significantly, EGS sites had higher levels of soil nitrogen, and significantly higher levels of iron, lead, arsenic, and chromium in the herbage. Toxic Ranunculus spp. (buttercups) were found in abundance at every EGS site, making ingestion plausible. Conversely, neurotoxin-producing cyanobacteria were not found in any of the water samples analyzed. Conclusions: The significantly higher levels of iron and heavy metals found in herbage growing in EGS sites, in addition to toxic Ranunculus species, suggest that previously unknown triggers are involved in a multi-factorial EGS etiology. Our results also show that cyanobacteria on the other hand, are unlikely to be a factor in EGS. Consequently, the concomitant presence of two (or more) factors could be the trigger for an outbreak of EGS. Frontiers Research Foundation 2010-10-25 /pmc/articles/PMC3153002/ /pubmed/21833167 http://dx.doi.org/10.3389/fphar.2010.00122 Text en Copyright © 2010 Edwards, Martz, Rogge and Heinrich. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Edwards, Sarah E.
Martz, Kathrin E.
Rogge, Anja
Heinrich, Michael
Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title_full Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title_fullStr Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title_full_unstemmed Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title_short Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK
title_sort edaphic and phytochemical factors as predictors of equine grass sickness cases in the uk
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153002/
https://www.ncbi.nlm.nih.gov/pubmed/21833167
http://dx.doi.org/10.3389/fphar.2010.00122
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