Stereoselective Inhibition of the hERG1 Potassium Channel

A growing number of drugs have been shown to prolong cardiac repolarization, predisposing individuals to life-threatening ventricular arrhythmias known as Torsades de Pointes. Most of these drugs are known to interfere with the human ether à-gogo related gene 1 (hERG1) channel, whose current is one...

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Detalles Bibliográficos
Autores principales: Grilo, Liliana Sintra, Carrupt, Pierre-Alain, Abriel, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153011/
https://www.ncbi.nlm.nih.gov/pubmed/21833176
http://dx.doi.org/10.3389/fphar.2010.00137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153011/
https://www.ncbi.nlm.nih.gov/pubmed/21833176
http://dx.doi.org/10.3389/fphar.2010.00137

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