Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes

Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differ...

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Detalles Bibliográficos
Autores principales: Taneja, Pankaj, Zhu, Sinan, Maglic, Dejan, Fry, Elizabeth A., Kendig, Robert D., Inoue, Kazushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153120/
https://www.ncbi.nlm.nih.gov/pubmed/21836819
http://dx.doi.org/10.4137/CMO.S7516
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author Taneja, Pankaj
Zhu, Sinan
Maglic, Dejan
Fry, Elizabeth A.
Kendig, Robert D.
Inoue, Kazushi
author_facet Taneja, Pankaj
Zhu, Sinan
Maglic, Dejan
Fry, Elizabeth A.
Kendig, Robert D.
Inoue, Kazushi
author_sort Taneja, Pankaj
collection PubMed
description Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. Tumor suppressor mouse models are the most frequently used animal models in cancer research. The anti-tumorigenic functions of TSGs, and their role in development and differentiation, and inhibition of oncogenes are discussed. In this review, we summarize some of the important transgenic and knockout mouse models for TSGs, including Rb, p53, Ink4a/Arf, Brca1/2, and their related genes.
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spelling pubmed-31531202011-08-11 Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes Taneja, Pankaj Zhu, Sinan Maglic, Dejan Fry, Elizabeth A. Kendig, Robert D. Inoue, Kazushi Clin Med Insights Oncol Review Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. Tumor suppressor mouse models are the most frequently used animal models in cancer research. The anti-tumorigenic functions of TSGs, and their role in development and differentiation, and inhibition of oncogenes are discussed. In this review, we summarize some of the important transgenic and knockout mouse models for TSGs, including Rb, p53, Ink4a/Arf, Brca1/2, and their related genes. Libertas Academica 2011-07-28 /pmc/articles/PMC3153120/ /pubmed/21836819 http://dx.doi.org/10.4137/CMO.S7516 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Review
Taneja, Pankaj
Zhu, Sinan
Maglic, Dejan
Fry, Elizabeth A.
Kendig, Robert D.
Inoue, Kazushi
Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title_full Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title_fullStr Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title_full_unstemmed Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title_short Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
title_sort transgenic and knockout mice models to reveal the functions of tumor suppressor genes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153120/
https://www.ncbi.nlm.nih.gov/pubmed/21836819
http://dx.doi.org/10.4137/CMO.S7516
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