Cargando…

IKKβ Activation Is Sufficient for RANK-Independent Osteoclast Differentiation and Osteolysis

Monocytes differentiate into osteoclasts through stimulation of receptor activator of NF-κB (RANK). Many downstream effectors of RANK play a positive role in osteoclastogenesis, but their relative importance in osteoclast differentiation is unclear. We report the discovery that activation of a singl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Otero, Jesse E, Dai, Simon, Alhawagri, Muhammad A, Darwech, Isra, Abu-Amer, Yousef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153134/ https://www.ncbi.nlm.nih.gov/pubmed/20200955 http://dx.doi.org/10.1002/jbmr.4

Ejemplares similares

Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies
por: Abu-Amer, Yousef, et al.
Publicado: (2007)

Osteoclasts; culprits in inflammatory osteolysis
por: Teitelbaum, Steven L
Publicado: (2006)

Pharmacological Inhibition of the Skeletal IKKβ Reduces Breast Cancer-Induced Osteolysis
por: Marino, Silvia, et al.
Publicado: (2018)

Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis
por: Jung, Youn-Kwan, et al.
Publicado: (2019)

Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis
por: Kim, Nacksung, et al.
Publicado: (2005)

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis
por: Yang, Chang, et al.
Publicado: (2010)

Phillyrin Prevents Ovariectomy-Induced Osteolysis by Inhibiting Osteoclast Differentiation
por: Zhang, Geng, et al.
Publicado: (2022)

IKKe in osteoclast inhibits the progression of methylprednisolone-induced osteonecrosis
por: Liu, Yingjie, et al.
Publicado: (2021)

Paeoniflorin Inhibits Receptor Activator for Nuclear Factor κB (RANK) Ligand-Induced Osteoclast Differentiation In Vitro and Particle-Induced Osteolysis In Vivo
por: Li, Zhuokai, et al.
Publicado: (2018)

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
por: Olivotto, Eleonora, et al.
Publicado: (2015)

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
por: Ruocco, Maria Grazia, et al.
Publicado: (2005)

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
por: Adapala, Naga Suresh, et al.
Publicado: (2020)

Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
por: Wang, Jing, et al.
Publicado: (2019)

Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis
por: Yin, Zhaoyang, et al.
Publicado: (2023)

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
por: Prescott, Jack A., et al.
Publicado: (2018)

Ranking the university stars: are opinions sufficient?
por: van der Wall, E. E.
Publicado: (2014)

The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis
por: Shen, Zhenxin, et al.
Publicado: (2006)

Constitutive Activation of IKK2/NF-κB Impairs Osteogenesis and Skeletal Development
por: Swarnkar, Gaurav, et al.
Publicado: (2014)

Physiologic osteoclasts are not sufficient to induce skeletal pain in mice
por: de Clauser, Larissa, et al.
Publicado: (2020)

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts
por: Fuller, Karen, et al.
Publicado: (1998)

The Role of RANKL/RANK/OPG System in the Canine Model of Hip Periprosthetic Infection Osteolysis
por: Zhang, Hao-Wei, et al.
Publicado: (2017)

Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation
por: Jiao, Zixian, et al.
Publicado: (2017)

Targeting Anion Exchange of Osteoclast, a New Strategy for Preventing Wear Particles Induced- Osteolysis
por: Wu, Chuanlong, et al.
Publicado: (2018)

Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways
por: Liu, Xuan, et al.
Publicado: (2022)

Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation
por: Park, Jin Hee, et al.
Publicado: (2017)

Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts
por: Feng, Ming-Xuan, et al.
Publicado: (2016)

Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells
por: Wang, Qiang, et al.
Publicado: (2018)

Corrigendum: Targeting Anion Exchange of Osteoclast, a New Strategy for Preventing Wear Particles Induced-Osteolysis
por: Wu, Chuanlong, et al.
Publicado: (2019)

Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients
por: Han, Yujie, et al.
Publicado: (2021)

Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts
por: Li, Tao, et al.
Publicado: (2021)

Desferrioxamine alleviates UHMWPE particle-induced osteoclastic osteolysis by inhibiting caspase-1-dependent pyroptosis in osteocytes
por: Zhao, Shenli, et al.
Publicado: (2022)

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
por: Zhang, Jiazhen, et al.
Publicado: (2014)

The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation
por: Wu, Yanglin, et al.
Publicado: (2022)

Prevention of Wear Particle-Induced Osteolysis by a Novel V-ATPase Inhibitor Saliphenylhalamide through Inhibition of Osteoclast Bone Resorption
por: Qin, An, et al.
Publicado: (2012)

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
por: Khoshnan, Ali, et al.
Publicado: (2009)

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
por: Kobayashi, Kanichiro, et al.
Publicado: (2000)

Corrigendum: Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast cancer cells and osteoclasts
por: Feng, Ming-Xuan, et al.
Publicado: (2018)

Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Formation
por: Zhu, Fangbing, et al.
Publicado: (2021)

Conditional knockout of PDK1 in osteoclasts suppressed osteoclastogenesis and ameliorated prostate cancer-induced osteolysis in murine model
por: Zhang, Yanan, et al.
Publicado: (2023)

Cell Adhesion Signaling Regulates RANK Expression in Osteoclast Precursors
por: Mochizuki, Ayako, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_brsr0u00h1pifrv5h31rv7fa74