Mechanisms of Cisplatin Nephrotoxicity

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become appa...

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Detalles Bibliográficos
Autores principales: Miller, Ronald P., Tadagavadi, Raghu K., Ramesh, Ganesan, Reeves, William Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153174/
https://www.ncbi.nlm.nih.gov/pubmed/22069563
http://dx.doi.org/10.3390/toxins2112490
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author Miller, Ronald P.
Tadagavadi, Raghu K.
Ramesh, Ganesan
Reeves, William Brian
author_facet Miller, Ronald P.
Tadagavadi, Raghu K.
Ramesh, Ganesan
Reeves, William Brian
author_sort Miller, Ronald P.
collection PubMed
description Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
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spelling pubmed-31531742011-11-08 Mechanisms of Cisplatin Nephrotoxicity Miller, Ronald P. Tadagavadi, Raghu K. Ramesh, Ganesan Reeves, William Brian Toxins (Basel) Review Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention. MDPI 2010-10-26 /pmc/articles/PMC3153174/ /pubmed/22069563 http://dx.doi.org/10.3390/toxins2112490 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Miller, Ronald P.
Tadagavadi, Raghu K.
Ramesh, Ganesan
Reeves, William Brian
Mechanisms of Cisplatin Nephrotoxicity
title Mechanisms of Cisplatin Nephrotoxicity
title_full Mechanisms of Cisplatin Nephrotoxicity
title_fullStr Mechanisms of Cisplatin Nephrotoxicity
title_full_unstemmed Mechanisms of Cisplatin Nephrotoxicity
title_short Mechanisms of Cisplatin Nephrotoxicity
title_sort mechanisms of cisplatin nephrotoxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153174/
https://www.ncbi.nlm.nih.gov/pubmed/22069563
http://dx.doi.org/10.3390/toxins2112490
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