A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology

DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid...

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Autores principales: Mantle, Peter G., Amerasinghe, Cyrille, Brown, Amy L., Herman, Diana, Horn, Thomas, Krogh, Thoger, Odell, Edward W., Rosenbaum, Tomas, Tatu, Calin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153191/
https://www.ncbi.nlm.nih.gov/pubmed/22069587
http://dx.doi.org/10.3390/toxins2030326
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author Mantle, Peter G.
Amerasinghe, Cyrille
Brown, Amy L.
Herman, Diana
Horn, Thomas
Krogh, Thoger
Odell, Edward W.
Rosenbaum, Tomas
Tatu, Calin A.
author_facet Mantle, Peter G.
Amerasinghe, Cyrille
Brown, Amy L.
Herman, Diana
Horn, Thomas
Krogh, Thoger
Odell, Edward W.
Rosenbaum, Tomas
Tatu, Calin A.
author_sort Mantle, Peter G.
collection PubMed
description DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.
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spelling pubmed-31531912011-11-08 A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology Mantle, Peter G. Amerasinghe, Cyrille Brown, Amy L. Herman, Diana Horn, Thomas Krogh, Thoger Odell, Edward W. Rosenbaum, Tomas Tatu, Calin A. Toxins (Basel) Article DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model. Molecular Diversity Preservation International 2010-03-09 /pmc/articles/PMC3153191/ /pubmed/22069587 http://dx.doi.org/10.3390/toxins2030326 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mantle, Peter G.
Amerasinghe, Cyrille
Brown, Amy L.
Herman, Diana
Horn, Thomas
Krogh, Thoger
Odell, Edward W.
Rosenbaum, Tomas
Tatu, Calin A.
A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title_full A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title_fullStr A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title_full_unstemmed A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title_short A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
title_sort pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153191/
https://www.ncbi.nlm.nih.gov/pubmed/22069587
http://dx.doi.org/10.3390/toxins2030326
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