Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum

Cholera toxin (CT), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER). In the ER, a portion of CT, the enzymatic A1-chain, is unfolded by protein disulfide is...

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Detalles Bibliográficos
Autores principales: Wernick, Naomi L. B., Chinnapen, Daniel J.-F., Cho, Jin Ah, Lencer, Wayne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153193/
https://www.ncbi.nlm.nih.gov/pubmed/22069586
http://dx.doi.org/10.3390/toxins2030310

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