Inhibition of Hemorragic Snake Venom Components: Old and New Approaches

Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxin...

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Detalles Bibliográficos
Autores principales: Panfoli, Isabella, Calzia, Daniela, Ravera, Silvia, Morelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153198/
https://www.ncbi.nlm.nih.gov/pubmed/22069593
http://dx.doi.org/10.3390/toxins2040417
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author Panfoli, Isabella
Calzia, Daniela
Ravera, Silvia
Morelli, Alessandro
author_facet Panfoli, Isabella
Calzia, Daniela
Ravera, Silvia
Morelli, Alessandro
author_sort Panfoli, Isabella
collection PubMed
description Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy.
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spelling pubmed-31531982011-11-08 Inhibition of Hemorragic Snake Venom Components: Old and New Approaches Panfoli, Isabella Calzia, Daniela Ravera, Silvia Morelli, Alessandro Toxins (Basel) Review Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy. Molecular Diversity Preservation International 2010-03-25 /pmc/articles/PMC3153198/ /pubmed/22069593 http://dx.doi.org/10.3390/toxins2040417 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Panfoli, Isabella
Calzia, Daniela
Ravera, Silvia
Morelli, Alessandro
Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title_full Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title_fullStr Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title_full_unstemmed Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title_short Inhibition of Hemorragic Snake Venom Components: Old and New Approaches
title_sort inhibition of hemorragic snake venom components: old and new approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153198/
https://www.ncbi.nlm.nih.gov/pubmed/22069593
http://dx.doi.org/10.3390/toxins2040417
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