Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE...

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Detalles Bibliográficos
Autor principal: Stoev, Stoycho D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153202/
https://www.ncbi.nlm.nih.gov/pubmed/22069604
http://dx.doi.org/10.3390/toxins2040649
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author Stoev, Stoycho D.
author_facet Stoev, Stoycho D.
author_sort Stoev, Stoycho D.
collection PubMed
description Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
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spelling pubmed-31532022011-11-08 Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks Stoev, Stoycho D. Toxins (Basel) Article Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver. Molecular Diversity Preservation International 2010-04-12 /pmc/articles/PMC3153202/ /pubmed/22069604 http://dx.doi.org/10.3390/toxins2040649 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Stoev, Stoycho D.
Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title_full Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title_fullStr Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title_full_unstemmed Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title_short Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
title_sort studies on carcinogenic and toxic effects of ochratoxin a in chicks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153202/
https://www.ncbi.nlm.nih.gov/pubmed/22069604
http://dx.doi.org/10.3390/toxins2040649
work_keys_str_mv AT stoevstoychod studiesoncarcinogenicandtoxiceffectsofochratoxinainchicks

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