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Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers

The individual and combined effects of dietary aflatoxin B(1 )(AFB(1)) and fumonisin B(1) (FB(1)) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arr...

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Autores principales: Tessari, Eliana N. C., Kobashigawa, Estela, Cardoso, Ana Lúcia S. P., Ledoux, David R., Rottinghaus, George E., Oliveira, Carlos A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153208/
https://www.ncbi.nlm.nih.gov/pubmed/22069595
http://dx.doi.org/10.3390/toxins2040453
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author Tessari, Eliana N. C.
Kobashigawa, Estela
Cardoso, Ana Lúcia S. P.
Ledoux, David R.
Rottinghaus, George E.
Oliveira, Carlos A. F.
author_facet Tessari, Eliana N. C.
Kobashigawa, Estela
Cardoso, Ana Lúcia S. P.
Ledoux, David R.
Rottinghaus, George E.
Oliveira, Carlos A. F.
author_sort Tessari, Eliana N. C.
collection PubMed
description The individual and combined effects of dietary aflatoxin B(1 )(AFB(1)) and fumonisin B(1) (FB(1)) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB(1 )(0, 50 and 200 μg AFB(1)/kg), and three levels of FB(1 )(0, 50 and 200 mg FB(1)/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB(1 )only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 μg AFB(1)/kg alone or in combination with FB(1). At day 33 days post feeding, with the exception of birds fed the highest combination of AFB(1 )and FB(1 )which had higher plasma TP than control birds(, )plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB(1) and FB(1) had bile duct proliferation and trabecular disorder in liver samples. AFB(1) singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST.
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spelling pubmed-31532082011-11-08 Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers Tessari, Eliana N. C. Kobashigawa, Estela Cardoso, Ana Lúcia S. P. Ledoux, David R. Rottinghaus, George E. Oliveira, Carlos A. F. Toxins (Basel) Article The individual and combined effects of dietary aflatoxin B(1 )(AFB(1)) and fumonisin B(1) (FB(1)) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB(1 )(0, 50 and 200 μg AFB(1)/kg), and three levels of FB(1 )(0, 50 and 200 mg FB(1)/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB(1 )only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 μg AFB(1)/kg alone or in combination with FB(1). At day 33 days post feeding, with the exception of birds fed the highest combination of AFB(1 )and FB(1 )which had higher plasma TP than control birds(, )plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB(1) and FB(1) had bile duct proliferation and trabecular disorder in liver samples. AFB(1) singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST. Molecular Diversity Preservation International 2010-03-29 /pmc/articles/PMC3153208/ /pubmed/22069595 http://dx.doi.org/10.3390/toxins2040453 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tessari, Eliana N. C.
Kobashigawa, Estela
Cardoso, Ana Lúcia S. P.
Ledoux, David R.
Rottinghaus, George E.
Oliveira, Carlos A. F.
Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title_full Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title_fullStr Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title_full_unstemmed Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title_short Effects of Aflatoxin B(1) and Fumonisin B(1) on Blood Biochemical Parameters in Broilers
title_sort effects of aflatoxin b(1) and fumonisin b(1) on blood biochemical parameters in broilers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153208/
https://www.ncbi.nlm.nih.gov/pubmed/22069595
http://dx.doi.org/10.3390/toxins2040453
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