Ochratoxin A and β2-Microglobulin in BEN Patients and Controls

Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impair...

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Autores principales: Yordanova, Pavlina, Wilfried, Karmaus, Tsolova, Svetla, Dimitrov, Plamen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153209/
https://www.ncbi.nlm.nih.gov/pubmed/22069610
http://dx.doi.org/10.3390/toxins2040780
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author Yordanova, Pavlina
Wilfried, Karmaus
Tsolova, Svetla
Dimitrov, Plamen
author_facet Yordanova, Pavlina
Wilfried, Karmaus
Tsolova, Svetla
Dimitrov, Plamen
author_sort Yordanova, Pavlina
collection PubMed
description Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
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spelling pubmed-31532092011-11-08 Ochratoxin A and β2-Microglobulin in BEN Patients and Controls Yordanova, Pavlina Wilfried, Karmaus Tsolova, Svetla Dimitrov, Plamen Toxins (Basel) Article Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN. MDPI 2010-04-20 /pmc/articles/PMC3153209/ /pubmed/22069610 http://dx.doi.org/10.3390/toxins2040780 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yordanova, Pavlina
Wilfried, Karmaus
Tsolova, Svetla
Dimitrov, Plamen
Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title_full Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title_fullStr Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title_full_unstemmed Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title_short Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
title_sort ochratoxin a and β2-microglobulin in ben patients and controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153209/
https://www.ncbi.nlm.nih.gov/pubmed/22069610
http://dx.doi.org/10.3390/toxins2040780
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AT tsolovasvetla ochratoxinaandb2microglobulininbenpatientsandcontrols
AT dimitrovplamen ochratoxinaandb2microglobulininbenpatientsandcontrols

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