Cargando…

The Enterotoxicity of Clostridium difficile Toxins

The major virulence factors of Clostridium difficile infection (CDI) are two large exotoxins A (TcdA) and B (TcdB). However, our understanding of the specific roles of these toxins in CDI is still evolving. It is now accepted that both toxins are enterotoxic and proinflammatory in the human intestin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Xingmin, Savidge, Tor, Feng, Hanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153265/ https://www.ncbi.nlm.nih.gov/pubmed/22069662 http://dx.doi.org/10.3390/toxins2071848

Ejemplares similares

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
por: Yang, Guilin, et al.
Publicado: (2008)

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity
por: Zhang, Yongrong, et al.
Publicado: (2013)

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B
por: Chen, Shuyi, et al.
Publicado: (2016)

Identification of Toxemia in Patients with Clostridium difficile Infection
por: Yu, Hua, et al.
Publicado: (2015)

Structure of the full-length Clostridium difficile toxin B
por: Chen, Peng, et al.
Publicado: (2019)

Utility of Clostridium difficile Toxin B for Inducing Anti-Tumor Immunity
por: Huang, Tuxiong, et al.
Publicado: (2014)

The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
por: Chen, Shuyi, et al.
Publicado: (2015)

Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity
por: Zhang, Yongrong, et al.
Publicado: (2018)

Correction: Chen, S., et al. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins 2016, 8, 241
por: Chen, Shuyi, et al.
Publicado: (2016)

Antibiotic Resistance and Toxin Production of Clostridium difficile Isolates from the Hospitalized Patients in a Large Hospital in Florida
por: Peng, Zhong, et al.
Publicado: (2017)

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis
por: Martin-Verstraete, Isabelle, et al.
Publicado: (2016)

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
por: Yuan, Pengfei, et al.
Publicado: (2015)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Toxin B is essential for virulence of Clostridium difficile
por: Lyras, Dena, et al.
Publicado: (2009)

The Association between GABA-Modulators and Clostridium difficile Infection – A Matched Retrospective Case-Control Study
por: Ström, Jonathan, et al.
Publicado: (2017)

Novel Chimeric Protein Vaccines Against Clostridium difficile Infection
por: Wang, Shaohui, et al.
Publicado: (2018)

Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
por: Dornisch, Elisabeth, et al.
Publicado: (2017)

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
por: Krautz-Peterson, Greice, et al.
Publicado: (2012)

Binary Toxin and Death after Clostridium difficile Infection
por: Bacci, Sabrina, et al.
Publicado: (2011)

Spore Formation and Toxin Production in Clostridium difficile Biofilms
por: Semenyuk, Ekaterina G., et al.
Publicado: (2014)

Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
por: Giglio, Matías L., et al.
Publicado: (2020)

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives (†)
por: Hussack, Greg, et al.
Publicado: (2010)

Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance
por: Gerding, Dale N, et al.
Publicado: (2014)

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects
por: Di Bella, Stefano, et al.
Publicado: (2016)

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
por: Schnell, Leonie, et al.
Publicado: (2016)

Methotrexate enterotoxicity: influence of drug dose and timing in the rat.
por: Pinkerton, C. R., et al.
Publicado: (1984)

Lycopene Maintains Mitochondrial Homeostasis to Counteract the Enterotoxicity of Deoxynivalenol
por: Cai, Zihui, et al.
Publicado: (2023)

Clostridium difficile Infection Caused by Binary Toxin–Positive Strains
por: Hensgens, Marjolein P.M., et al.
Publicado: (2013)

Genes Encoding Toxin of Clostridium difficile in Children with and without Diarrhea
por: Merino, Victor R. C., et al.
Publicado: (2014)

Toxin Synthesis by Clostridium difficile Is Regulated through Quorum Signaling
por: Darkoh, Charles, et al.
Publicado: (2015)

Increased toxin expression in a Clostridium difficile mfd mutant
por: Willing, Stephanie E., et al.
Publicado: (2015)

Frizzled are colonic epithelial receptors for Clostridium difficile toxin B
por: Tao, Liang, et al.
Publicado: (2016)

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B
por: Frädrich, Claudia, et al.
Publicado: (2016)

Pulsed-field gel electrophoresis of enterotoxic Clostridium perfringens type A isolates recovered from humans and animals in Kolkata, India
por: Yadav, Jay P., et al.
Publicado: (2017)

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
por: Kuehne, Sarah A., et al.
Publicado: (2014)

A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters
por: Wang, Yuan-Kai, et al.
Publicado: (2015)

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
por: Shen, Aimee, et al.
Publicado: (2011)

Toward a structural understanding of Clostridium difficile toxins A and B
por: Pruitt, Rory N., et al.
Publicado: (2012)

Proteomic Analysis and Label-Free Quantification of the Large Clostridium difficile Toxins
por: Moura, Hercules, et al.
Publicado: (2013)

Bile Salt Inhibition of Host Cell Damage by Clostridium Difficile Toxins
por: Darkoh, Charles, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vf969l568pv59jjjc64br5vt01