Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection

An estimated 4 billion episodes of diarrhea occur each year. As a result, 2–3 million children and 0.5–1 million adults succumb to the consequences of this major healthcare concern. The majority of these deaths can be attributed to toxin mediated diarrhea by infectious agents, such as E. coli, V. ch...

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Autores principales: Kopic, Sascha, Geibel, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153279/
https://www.ncbi.nlm.nih.gov/pubmed/22069677
http://dx.doi.org/10.3390/toxins2082132
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author Kopic, Sascha
Geibel, John P.
author_facet Kopic, Sascha
Geibel, John P.
author_sort Kopic, Sascha
collection PubMed
description An estimated 4 billion episodes of diarrhea occur each year. As a result, 2–3 million children and 0.5–1 million adults succumb to the consequences of this major healthcare concern. The majority of these deaths can be attributed to toxin mediated diarrhea by infectious agents, such as E. coli, V. cholerae or Rotavirus. Our understanding of the pathophysiological processes underlying these infectious diseases has notably improved over the last years. This review will focus on the cellular mechanism of action of the most common enterotoxins and the latest specific therapeutic approaches that have been developed to contain their lethal effects.
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spelling pubmed-31532792011-11-08 Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection Kopic, Sascha Geibel, John P. Toxins (Basel) Review An estimated 4 billion episodes of diarrhea occur each year. As a result, 2–3 million children and 0.5–1 million adults succumb to the consequences of this major healthcare concern. The majority of these deaths can be attributed to toxin mediated diarrhea by infectious agents, such as E. coli, V. cholerae or Rotavirus. Our understanding of the pathophysiological processes underlying these infectious diseases has notably improved over the last years. This review will focus on the cellular mechanism of action of the most common enterotoxins and the latest specific therapeutic approaches that have been developed to contain their lethal effects. MDPI 2010-08-10 /pmc/articles/PMC3153279/ /pubmed/22069677 http://dx.doi.org/10.3390/toxins2082132 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kopic, Sascha
Geibel, John P.
Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title_full Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title_fullStr Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title_full_unstemmed Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title_short Toxin Mediated Diarrhea in the 21(st) Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
title_sort toxin mediated diarrhea in the 21(st) century: the pathophysiology of intestinal ion transport in the course of etec, v. cholerae and rotavirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153279/
https://www.ncbi.nlm.nih.gov/pubmed/22069677
http://dx.doi.org/10.3390/toxins2082132
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